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Issue 40, 2015
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Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers

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Abstract

Enhancing the immunogenicity of an antitumour vaccine still poses a major challenge. It depends upon the selected antigen and the mode of its presentation. We here describe a fully synthetic antitumour vaccine, which addresses both aspects. For the antigen, a tumour-associated MUC1 glycopeptide as B-cell epitope was synthesised and linked to the immunostimulating T-cell epitope P2 derived from tetanus toxoid. The MUC1-P2 conjugate is presented multivalently on a hyperbranched polyglycerol to the immune system. In comparison to a related vaccine of lower multivalency, this vaccine exposing more antigen structures on the hyperbranched polymer induced significantly stronger immune responses in mice and elicited IgG antibodies of distinctly higher affinity to epithelial tumour cells.

Graphical abstract: Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers

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Publication details

The article was received on 18 Jun 2015, accepted on 17 Aug 2015 and first published on 18 Aug 2015


Article type: Paper
DOI: 10.1039/C5OB01255D
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Citation: Org. Biomol. Chem., 2015,13, 10150-10154
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    Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers

    M. Glaffig, B. Palitzsch, N. Stergiou, C. Schüll, D. Straßburger, E. Schmitt, H. Frey and H. Kunz, Org. Biomol. Chem., 2015, 13, 10150
    DOI: 10.1039/C5OB01255D

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