Issue 33, 2015
From the journal:

Organic & Biomolecular Chemistry

Phosphonate monoesters on a thiacalix[4]arene framework as potential inhibitors of protein tyrosine phosphatase 1B†

Viacheslav V. Trush,a   Sergiy G. Kharchenko,b   Vsevolod Yu. Tanchuk,a   Vitaly I. Kalchenkob  and  Andriy I. Vovk*a  

* Corresponding authors

a Department of Bioorganic Mechanisms, Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine, Kyiv, Ukraine
E-mail: vovk@bpci.kiev.ua

b Department of Phosphoranes Chemistry, Institute of Organic Chemistry of National Academy of Sciences of Ukraine, Kyiv, Ukraine

Abstract

Monoester derivatives of thiacalix[4]arene tetrakis(methylphosphonic) acid were found to be capable of inhibiting protein tyrosine phosphatase 1B. In addition, these compounds can strongly bind to human serum albumin.

Graphical abstract: Phosphonate monoesters on a thiacalix[4]arene framework as potential inhibitors of protein tyrosine phosphatase 1B

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Article information

DOI
https://doi.org/10.1039/C5OB01247C
Article type
Communication
Submitted
18 Jun 2015
Accepted
16 Jul 2015
First published
16 Jul 2015

Org. Biomol. Chem., 2015,13, 8803-8806

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Phosphonate monoesters on a thiacalix[4]arene framework as potential inhibitors of protein tyrosine phosphatase 1B

V. V. Trush, S. G. Kharchenko, V. Yu. Tanchuk, V. I. Kalchenko and A. I. Vovk, Org. Biomol. Chem., 2015, 13, 8803 DOI: 10.1039/C5OB01247C

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