Issue 35, 2015

Ruthenium-catalyzed cyclization of N-carbamoyl indolines with alkynes: an efficient route to pyrroloquinolinones

Abstract

A regioselective synthesis of substituted pyrroloquinolinones via a ruthenium-catalyzed oxidative cyclization of substituted N-carbamoyl indolines with alkynes is described. The cyclization reaction was compatible with various symmetrical and unsymmetrical alkynes including substituted propiolates. Later, we performed the aromatization of pyrroloquinolinones into indole derivatives in the presence of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ).

Graphical abstract: Ruthenium-catalyzed cyclization of N-carbamoyl indolines with alkynes: an efficient route to pyrroloquinolinones

Supplementary files

Article information

Article type
Paper
Submitted
08 Jun 2015
Accepted
09 Jul 2015
First published
13 Jul 2015

Org. Biomol. Chem., 2015,13, 9276-9284

Author version available

Ruthenium-catalyzed cyclization of N-carbamoyl indolines with alkynes: an efficient route to pyrroloquinolinones

R. Manoharan and M. Jeganmohan, Org. Biomol. Chem., 2015, 13, 9276 DOI: 10.1039/C5OB01146A

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