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Issue 26, 2015
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The expanding utility of continuous flow hydrogenation

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Abstract

There has been an increasing body of evidence that flow hydrogenation enhances reduction outcomes across a wide range of synthetic transformations. Moreover flow reactors enhance laboratory safety with pyrophoric catalysts contained in sealed cartridges and hydrogen generated in situ from water. This mini-review focuses on recent applications of flow chemistry to mediate nitro, imine, nitrile, amide, azide, and azo reductions. Methodologies to effect de-aromatisation, hydrodehalogenation, in addition to olefin, alkyne, carbonyl, and benzyl reductions are also examined. Further, protocols to effect chemoselective reductions and enantioselective reductions are highlighted. Together these applications demonstrate the numerous advantages of performing hydrogenation under flow conditions which include enhanced reaction throughput, yields, simplified workup, and the potential applicability to multistep and cascade synthetic protocols.

Graphical abstract: The expanding utility of continuous flow hydrogenation

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Article information


Submitted
27 May 2015
Accepted
09 Jun 2015
First published
09 Jun 2015

Org. Biomol. Chem., 2015,13, 7119-7130
Article type
Review Article
Author version available

The expanding utility of continuous flow hydrogenation

P. J. Cossar, L. Hizartzidis, M. I. Simone, A. McCluskey and C. P. Gordon, Org. Biomol. Chem., 2015, 13, 7119
DOI: 10.1039/C5OB01067E

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