Issue 30, 2015

Short and highly efficient synthesis of lipid peroxidation inhibitor pyrrolostatin and some analogues thereof

Abstract

A highly efficient and scalable synthesis of potent lipid peroxidation inhibitor pyrrolostatin is reported (4 steps, 48%). In addition to the synthesis of the natural product, strategies for the preparation of analogues differing in the three structural subunits, the polar head group, the N-substituent and the lipophilic tail are described.

Graphical abstract: Short and highly efficient synthesis of lipid peroxidation inhibitor pyrrolostatin and some analogues thereof

Supplementary files

Article information

Article type
Communication
Submitted
26 May 2015
Accepted
25 Jun 2015
First published
25 Jun 2015

Org. Biomol. Chem., 2015,13, 8173-8176

Author version available

Short and highly efficient synthesis of lipid peroxidation inhibitor pyrrolostatin and some analogues thereof

J. Schmidt, J. Adrian and Christian B. W. Stark, Org. Biomol. Chem., 2015, 13, 8173 DOI: 10.1039/C5OB01066G

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