Issue 25, 2015

Mild electrophilic trifluoromethylthiolation of ketones with trifluoromethanesulfanamide

Abstract

A straightforward and convenient approach for trifluoromethylthiolation of various acyclic and cyclic ketones with PhNHSCF3 is described. The reaction proceeds smoothly in the presence of acetyl chloride at room temperature and affords α-trifluoromethylthiolated ketones in fair to good yields.

Graphical abstract: Mild electrophilic trifluoromethylthiolation of ketones with trifluoromethanesulfanamide

Supplementary files

Article information

Article type
Paper
Submitted
01 Apr 2015
Accepted
14 May 2015
First published
14 May 2015

Org. Biomol. Chem., 2015,13, 6992-6999

Author version available

Mild electrophilic trifluoromethylthiolation of ketones with trifluoromethanesulfanamide

W. Wu, X. Zhang, F. Liang and S. Cao, Org. Biomol. Chem., 2015, 13, 6992 DOI: 10.1039/C5OB00960J

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