β-Sheet mediated protein–protein interactions are involved in key signalling pathways in diseases such as cancer. We present small molecule β-strand mimetics and investigate their interactions with a model tripeptide. Using 1H NMR, the thermodynamic parameters for their binding are determined. These give insight into this biologically important interaction.
C. W. Robinson, C. S. Rye, N. E. A. Chessum and K. Jones, Org. Biomol. Chem., 2015, 13, 7402 DOI: 10.1039/C5OB00886G
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