Issue 21, 2015

An improved transition-metal-free synthesis of aryl alkynyl sulfides via substitution of a halide at an sp-centre

Abstract

A simple high-yielding preparation of aryl alkynyl sulfides is presented. The reaction of a chloroacetylene with a thiolate salt in the presence of an amine mediator (dimethylamine or N,N′-dimethylethylenediamine) yields the alkynyl sulfides in excellent yields. The alkynyl chloride is easily prepared from the parent alkyne.

Graphical abstract: An improved transition-metal-free synthesis of aryl alkynyl sulfides via substitution of a halide at an sp-centre

Supplementary files

Article information

Article type
Communication
Submitted
12 Mar 2015
Accepted
21 Apr 2015
First published
21 Apr 2015

Org. Biomol. Chem., 2015,13, 5859-5861

Author version available

An improved transition-metal-free synthesis of aryl alkynyl sulfides via substitution of a halide at an sp-centre

R. M. Chowdhury and J. D. Wilden, Org. Biomol. Chem., 2015, 13, 5859 DOI: 10.1039/C5OB00494B

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