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Issue 18, 2015

Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide

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Abstract

A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.

Graphical abstract: Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide

Supplementary files

Article information


Submitted
09 Mar 2015
Accepted
02 Apr 2015
First published
02 Apr 2015

Org. Biomol. Chem., 2015,13, 5098-5101
Article type
Communication
Author version available

Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide

B. Wu, N. Wei, V. Thon, M. Wei, Z. Yu, Y. Xu, X. Chen, J. Liu, P. G. Wang and T. Li, Org. Biomol. Chem., 2015, 13, 5098 DOI: 10.1039/C5OB00462D

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