Issue 20, 2015
From the journal:

Organic & Biomolecular Chemistry

Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase†

Jingming Zhao,a   Anna Kajetanowicza  and  Thomas R. Ward*a  

* Corresponding authors

a Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland
E-mail: thomas.ward@unibas.ch

Abstract

An artificial metathesase results from incorporation of an Hoveyda-Grubbs catalyst bearing an arylsulfonamide anchor within human carbonic anhydrase II. The optimization of the catalytic performance is achieved upon combining both chemical and genetic means. Up to 28 TONs were obtained within four hours under aerobic physiological conditions.

Graphical abstract: Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase

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Article information

DOI
https://doi.org/10.1039/C5OB00428D
Article type
Paper
Submitted
03 Mar 2015
Accepted
13 Apr 2015
First published
20 Apr 2015

Org. Biomol. Chem., 2015,13, 5652-5655

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Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase

J. Zhao, A. Kajetanowicz and T. R. Ward, Org. Biomol. Chem., 2015, 13, 5652 DOI: 10.1039/C5OB00428D

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