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Issue 11, 2015
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A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells

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Abstract

Cancer-related γ-glutamyl cyclotransferase (GGCT) specifically converts γ-glutamyl amino acids (γ-Glu-Xaa) into pyroglutamate and the corresponding amino acids (Xaa). Here we report a novel GGCT fluorogenic probe “LISA-101” containing a masked O-acylated fluorophore “resorufin” on the side chain of the P1 amino acid (Xaa). Upon GGCT treatment, the P1 amino acid was liberated and spontaneously released the intact fluorophore. Thus, the fluorescence was regained. LISA-101 will expand the strategies for cancer studies.

Graphical abstract: A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells

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Publication details

The article was received on 15 Jan 2015, accepted on 28 Jan 2015 and first published on 28 Jan 2015


Article type: Communication
DOI: 10.1039/C5OB00086F
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Citation: Org. Biomol. Chem., 2015,13, 3182-3185

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    A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells

    T. Yoshiya, H. Ii, S. Tsuda, S. Kageyama, T. Yoshiki and Y. Nishiuchi, Org. Biomol. Chem., 2015, 13, 3182
    DOI: 10.1039/C5OB00086F

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