Issue 11, 2015
From the journal:

Organic & Biomolecular Chemistry

PhI(OAc)2-mediated functionalisation of unactivated alkenes for the synthesis of pyrazoline and isoxazoline derivatives†

Xiao-Qiang Hu,a   Guoqiang Feng,a   Jia-Rong Chen,*a   Dong-Mei Yan,a   Quan-Qing Zhao,a   Qiang Weia  and  Wen-Jing Xiao*a  

* Corresponding authors

a Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
E-mail: chenjiarong@mail.ccnu.edu.cn, wxiao@mail.ccnu.edu.cn
Fax: +86 27 67862041
Tel: +86 27 67862041

Abstract

A PhI(OAc)2-promoted radical cyclization of β,γ-unsaturated hydrazones and oximes has been developed for an efficient synthesis of various valuable pyrazoline and isoxazoline derivatives with satisfactory yields (up to 96%) under mild conditions.

Graphical abstract: PhI(OAc)2-mediated functionalisation of unactivated alkenes for the synthesis of pyrazoline and isoxazoline derivatives

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Article information

DOI
https://doi.org/10.1039/C5OB00029G
Article type
Paper
Submitted
07 Jan 2015
Accepted
30 Jan 2015
First published
30 Jan 2015

Org. Biomol. Chem., 2015,13, 3457-3461

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PhI(OAc)2-mediated functionalisation of unactivated alkenes for the synthesis of pyrazoline and isoxazoline derivatives

X. Hu, G. Feng, J. Chen, D. Yan, Q. Zhao, Q. Wei and W. Xiao, Org. Biomol. Chem., 2015, 13, 3457 DOI: 10.1039/C5OB00029G

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