Issue 9, 2015

A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy

Abstract

The synthesis, structural characterization and the successful application of a carbon centered radical derived from 1,3-bisdiphenylene-2-phenylallyl (BDPA), its benzyl alcohol derivative (BA-BDPA), as a polarizing agent for Dynamic Nuclear Polarization (DNP) are described. The reported BA-BDPA radical meets all the requirements to become a promising candidate for its use in in vivo DNP-NMR experiments: it is soluble in neat [1-13C]pyruvic acid, insoluble in the dissolution transfer solvent and is effective as a polarizing agent in fast dissolution DNP-NMR applications, without the need for using glassing agents. Moreover, it enables a simple but effective in-line radical filtration to obtain hyperpolarized solutions of [1-13C]pyruvic acid free of radicals that offers a better polarization performance.

Graphical abstract: A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy

Supplementary files

Article information

Article type
Paper
Submitted
06 Nov 2014
Accepted
02 Jan 2015
First published
02 Jan 2015

Org. Biomol. Chem., 2015,13, 2689-2693

Author version available

A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy

J. L. Muñoz-Gómez, E. Monteagudo, V. Lloveras, T. Parella, J. Veciana and J. Vidal-Gancedo, Org. Biomol. Chem., 2015, 13, 2689 DOI: 10.1039/C4OB02356K

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