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Issue 9, 2015
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A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy

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Abstract

The synthesis, structural characterization and the successful application of a carbon centered radical derived from 1,3-bisdiphenylene-2-phenylallyl (BDPA), its benzyl alcohol derivative (BA-BDPA), as a polarizing agent for Dynamic Nuclear Polarization (DNP) are described. The reported BA-BDPA radical meets all the requirements to become a promising candidate for its use in in vivo DNP-NMR experiments: it is soluble in neat [1-13C]pyruvic acid, insoluble in the dissolution transfer solvent and is effective as a polarizing agent in fast dissolution DNP-NMR applications, without the need for using glassing agents. Moreover, it enables a simple but effective in-line radical filtration to obtain hyperpolarized solutions of [1-13C]pyruvic acid free of radicals that offers a better polarization performance.

Graphical abstract: A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy

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Article information


Submitted
06 Nov 2014
Accepted
02 Jan 2015
First published
02 Jan 2015

Org. Biomol. Chem., 2015,13, 2689-2693
Article type
Paper
Author version available

A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy

J. L. Muñoz-Gómez, E. Monteagudo, V. Lloveras, T. Parella, J. Veciana and J. Vidal-Gancedo, Org. Biomol. Chem., 2015, 13, 2689
DOI: 10.1039/C4OB02356K

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