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Issue 10, 2015
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Total synthesis of a thromboxane receptor antagonist, terutroban

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Abstract

A total synthesis of terutroban is achieved using the Claisen rearrangement, Friedel–Crafts acylation and Heck coupling as key reactions, avoiding the classical Diels–Alder approach used before.

Graphical abstract: Total synthesis of a thromboxane receptor antagonist, terutroban

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Publication details

The article was received on 29 Oct 2014, accepted on 06 Jan 2015 and first published on 06 Jan 2015


Article type: Paper
DOI: 10.1039/C4OB02302A
Org. Biomol. Chem., 2015,13, 2951-2957

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    Total synthesis of a thromboxane receptor antagonist, terutroban

    W. Ahmed, P. S. Mainkar, S. Pabbaraja and S. Chandrasekhar, Org. Biomol. Chem., 2015, 13, 2951
    DOI: 10.1039/C4OB02302A

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