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Issue 10, 2015
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Total synthesis of a thromboxane receptor antagonist, terutroban

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Abstract

A total synthesis of terutroban is achieved using the Claisen rearrangement, Friedel–Crafts acylation and Heck coupling as key reactions, avoiding the classical Diels–Alder approach used before.

Graphical abstract: Total synthesis of a thromboxane receptor antagonist, terutroban

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Supplementary files

Article information


Submitted
29 Oct 2014
Accepted
06 Jan 2015
First published
06 Jan 2015

Org. Biomol. Chem., 2015,13, 2951-2957
Article type
Paper

Total synthesis of a thromboxane receptor antagonist, terutroban

W. Ahmed, P. S. Mainkar, S. Pabbaraja and S. Chandrasekhar, Org. Biomol. Chem., 2015, 13, 2951
DOI: 10.1039/C4OB02302A

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