Issue 5, 2015

Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones

Abstract

In this work, we describe an accelerated solid-phase synthetic protocol for ordinary or difficult peptides involving air-bath heating and amide protection. For the Hmsb-based backbone amide protection, an optimized acyl shift condition using 1,4-dioxane was discovered. The efficiency and robustness of the protocol was validated in the course of preparation of classical difficult peptides and ubiquitin protein segments.

Graphical abstract: Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones

Supplementary files

Article information

Article type
Paper
Submitted
23 Oct 2014
Accepted
14 Nov 2014
First published
18 Nov 2014

Org. Biomol. Chem., 2015,13, 1500-1506

Author version available

Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones

Y. Huang, C. Guan, X. Tan, C. Chen, Q. Guo and Y. Li, Org. Biomol. Chem., 2015, 13, 1500 DOI: 10.1039/C4OB02260B

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