Issue 2, 2015
From the journal:

Organic & Biomolecular Chemistry

Rhodium(ii)-catalyzed intramolecular formal [4 + 3] cycloadditions of dienyltriazoles: rapid access to fused 2,5-dihydroazepines†

Yu Tian,a   Yuanhao Wang,b   Hai Shang,b   Xudong Xua  and  Yefeng Tang*bcd  

* Corresponding authors

a Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, P. R. China

b The Comprehensive AIDS Research Center, and The Department of Pharmacology & Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China
E-mail: yefengtang@tsinghua.edu.cn
Tel: +86 10 62798236

c Collaborative Innovation Center for Biotherapy, Tsinghua University, Beijing 100084, China

d Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, P.R. China

Abstract

Rhodium(II)-catalyzed intramolecular [4 + 3] cycloadditions of dienyltriazoles have been developed, which enable the efficient synthesis of various fused 2,5-dihydroazepines. Mechanistically, the titled reaction proceeds via an interesting tandem cyclopropanation/aza-cope rearrangement.

Graphical abstract: Rhodium(ii)-catalyzed intramolecular formal [4 + 3] cycloadditions of dienyltriazoles: rapid access to fused 2,5-dihydroazepines

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Article information

DOI
https://doi.org/10.1039/C4OB01910E
Article type
Paper
Submitted
09 Sep 2014
Accepted
29 Oct 2014
First published
30 Oct 2014

Org. Biomol. Chem., 2015,13, 612-619

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Rhodium(II)-catalyzed intramolecular formal [4 + 3] cycloadditions of dienyltriazoles: rapid access to fused 2,5-dihydroazepines

Y. Tian, Y. Wang, H. Shang, X. Xu and Y. Tang, Org. Biomol. Chem., 2015, 13, 612 DOI: 10.1039/C4OB01910E

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