Issue 44, 2015

Theranostic etoposide phosphate/indium nanoparticles for cancer therapy and imaging

Abstract

Etoposide phosphate (EP), a water-soluble anticancer prodrug, is widely used for treatment of many cancers. After administration it is rapidly converted to etoposide, its parent compound, which exhibits anticancer activity. Difficulty in parenteral administration necessitates the development of a suitable nanoparticle delivery system for EP. Here we have used indium both as a carrier to deliver etoposide phosphate to tumor cells and as a SPECT imaging agent through incorporation of 111In. Etoposide phosphate was successfully encapsulated together with indium in nanoparticles, and exhibited dose dependent cytotoxicity and induction of apoptosis in cultured H460 cancer cells via G2/M cell cycle arrest. In a mouse xenograft lung cancer model, etoposide phosphate/indium nanoparticles induce tumor cell apoptosis, leading to significant enhancement of tumor growth inhibition compared to the free drug.

Graphical abstract: Theranostic etoposide phosphate/indium nanoparticles for cancer therapy and imaging

Article information

Article type
Paper
Submitted
06 Jul 2015
Accepted
08 Oct 2015
First published
12 Oct 2015

Nanoscale, 2015,7, 18542-18551

Author version available

Theranostic etoposide phosphate/indium nanoparticles for cancer therapy and imaging

R. Srinivas, A. Satterlee, Y. Wang, Y. Zhang, Y. Wang and L. Huang, Nanoscale, 2015, 7, 18542 DOI: 10.1039/C5NR04509F

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