Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

Juliane Junesch; Gustav Emilsson; Kunli Xiong; Shailabh Kumar; Takumi Sannomiya; Hudson Pace; Janos Vörös; Sang-Hyun Oh; Marta Bally; Andreas B. Dahlin

doi:10.1039/C5NR04208A

Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature†

Juliane Junesch,^a Gustav Emilsson,‡^a Kunli Xiong,‡^a Shailabh Kumar,^b Takumi Sannomiya,^c Hudson Pace,^a Janos Vörös,^d Sang-Hyun Oh,^b Marta Bally^a and Andreas B. Dahlin*^a

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^a Department of Applied Physics, Chalmers University of Technology, 41296 Göteborg, Sweden
E-mail: adahlin@chalmers.se

^b Department of Electrical and Computer Engineering, University of Minnesota, 55455 Minneapolis, USA

^c Department of Innovative and Engineered Materials, Tokyo Institute of Technology, 226-8503 Yokohama, Japan

^d Department of Information Technology and Electrical Engineering, Swiss Federal Institute of Technology, 8092 Zürich, Switzerland

Abstract

The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic “nanowells” provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

Nanoscale

Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature†

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