Issue 38, 2015

A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy

Abstract

Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal–organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free “green” post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.

Graphical abstract: A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
24 Jun 2015
Accepted
24 Aug 2015
First published
27 Aug 2015

Nanoscale, 2015,7, 16061-16070

A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy

X. Wang, Z. Dong, H. Cheng, S. Wan, W. Chen, M. Zou, J. Huo, H. Deng and X. Zhang, Nanoscale, 2015, 7, 16061 DOI: 10.1039/C5NR04045K

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