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Issue 36, 2015
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Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

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Abstract

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron–oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T2 MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.

Graphical abstract: Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

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Supplementary files

Article information


Submitted
28 Apr 2015
Accepted
06 Aug 2015
First published
13 Aug 2015

This article is Open Access

Nanoscale, 2015,7, 14889-14896
Article type
Paper
Author version available

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

B. P. Burke, N. Baghdadi, A. E. Kownacka, S. Nigam, G. S. Clemente, M. M. Al-Yassiry, J. Domarkas, M. Lorch, M. Pickles, P. Gibbs, R. Tripier, C. Cawthorne and S. J. Archibald, Nanoscale, 2015, 7, 14889
DOI: 10.1039/C5NR02753E

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