Issue 25, 2015

A gold nanohole array based surface-enhanced Raman scattering biosensor for detection of silver(i) and mercury(ii) in human saliva

Abstract

A surface-enhanced Raman scattering (SERS) biosensor has been developed by incorporating a gold nanohole array with a SERS probe (a gold nanostar@Raman-reporter@silica sandwich structure) into a single detection platform via DNA hybridization, which circumvents the nanoparticle aggregation and the inefficient Raman scattering issues. Strong plasmonic coupling between the Au nanostar and the Au nanohole array results in a large enhancement of the electromagnetic field, leading to amplification of the SERS signal. The SERS sensor has been used to detect Ag(I) and Hg(II) ions in human saliva because both the metal ions could be released from dental amalgam fillings. The developed SERS sensor can be adapted as a general detection platform for non-invasive measurements of a wide range of analytes such as metal ions, small molecules, DNA and proteins in body fluids.

Graphical abstract: A gold nanohole array based surface-enhanced Raman scattering biosensor for detection of silver(i) and mercury(ii) in human saliva

Supplementary files

Article information

Article type
Paper
Submitted
03 Apr 2015
Accepted
07 May 2015
First published
11 May 2015

Nanoscale, 2015,7, 11005-11012

Author version available

A gold nanohole array based surface-enhanced Raman scattering biosensor for detection of silver(I) and mercury(II) in human saliva

P. Zheng, M. Li, R. Jurevic, S. K. Cushing, Y. Liu and N. Wu, Nanoscale, 2015, 7, 11005 DOI: 10.1039/C5NR02142A

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