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Issue 14, 2015
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Two-dimensional TiS2 nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy

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Abstract

Recently, transition metal dichalcogenides (TMDCs) have attracted significant attention in nanomedicine owing to their intriguing properties. In this study, TiS2 nanosheets, a new TMDC nanomaterial, are synthesized by a bottom-up solution-phase method and then modified with polyethylene glycol (PEG), obtaining TiS2-PEG with high stability in physiological solutions and no appreciable in vitro toxicity. Due to their high absorbance in the near-infrared (NIR) region, TiS2-PEG nanosheets could offer a strong contrast in photoacoustic imaging, which uncovers the high tumor uptake and retention of these nanosheets after systemic administration into tumor-bearing mice. We further apply TiS2-PEG nanosheets for in vivo photothermal therapy, which are able to completely eradicate the tumors in mice upon intravenous injection of TiS2-PEG followed by NIR laser irradiation. Our work indicates that TiS2 nanosheets with appropriate surface coating (e.g. PEGylation) would be a promising new class of photothermal agents for imaging-guided cancer therapy.

Graphical abstract: Two-dimensional TiS2 nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy

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Publication details

The article was received on 07 Feb 2015, accepted on 08 Mar 2015 and first published on 09 Mar 2015


Article type: Paper
DOI: 10.1039/C5NR00893J
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Citation: Nanoscale, 2015,7, 6380-6387
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    Two-dimensional TiS2 nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy

    X. Qian, S. Shen, T. Liu, L. Cheng and Z. Liu, Nanoscale, 2015, 7, 6380
    DOI: 10.1039/C5NR00893J

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