Jump to main content
Jump to site search

Issue 6, 2015
Previous Article Next Article

Facile integration of multiple magnetite nanoparticles for theranostics combining efficient MRI and thermal therapy

Author affiliations

Abstract

Multifunctional nanostructures with both diagnostic and therapeutic capabilities have attracted considerable attention in biomedical research because they can offer great advantages in disease management and prognosis. In this work, a facile way to transfer the hydrophobic iron oxide (IO) nanoparticles into aqueous media by employing carboxylic graphene oxide (GO-COOH) as the transferring agent has been reported. In this one-step process, IO nanoparticles adhere to GO-COOH and form water-dispersible clusters via hydrophobic interactions between the hydrophobic ligands of IO nanoparticles and the basal plane of GO-COOH. The multiple IO nanoparticles on GO-COOH sheets (IO/GO-COOH) present a significant increase in T2 contrast enhancement. Moreover, the IO/GO-COOH nanoclusters also display a high photothermal conversion efficiency and can effectively inhibit tumor growth through the photothermal effects. It is envisioned that such IO/GO-COOH nanocomposites combining efficient MRI and photothermal therapy hold great promise in theranostic applications.

Graphical abstract: Facile integration of multiple magnetite nanoparticles for theranostics combining efficient MRI and thermal therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Nov 2014, accepted on 23 Dec 2014 and first published on 26 Dec 2014


Article type: Paper
DOI: 10.1039/C4NR06616B
Citation: Nanoscale, 2015,7, 2667-2675
  •   Request permissions

    Facile integration of multiple magnetite nanoparticles for theranostics combining efficient MRI and thermal therapy

    G. Huang, X. Zhu, H. Li, L. Wang, X. Chi, J. Chen, X. Wang, Z. Chen and J. Gao, Nanoscale, 2015, 7, 2667
    DOI: 10.1039/C4NR06616B

Search articles by author

Spotlight

Advertisements