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Issue 9, 2015
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Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

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Abstract

The well-known reactive diuretic ethacrynic acid (EA, Edecrin), with low antiproliferative activities, was chemically modified and grafted onto phosphorus dendrimers and the corresponding simple branched phosphorus dendron-like derivatives affording novel nanodevices showing moderate to strong antiproliferative activities against liquid and solid tumor cell lines, respectively.

Graphical abstract: Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

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Submitted
10 Oct 2014
Accepted
26 Nov 2014
First published
01 Dec 2014

Nanoscale, 2015,7, 3915-3922
Article type
Paper
Author version available

Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

N. El Brahmi, S. M. Mignani, J. Caron, S. El Kazzouli, M. M. Bousmina, A. Caminade, T. Cresteil and J. Majoral, Nanoscale, 2015, 7, 3915
DOI: 10.1039/C4NR05983B

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