Issue 5, 2015
From the journal:

Nanoscale

Targeted labeling of an early-stage tumor spheroid in a chorioallantoic membrane model with upconversion nanoparticles†

Kai Liu,‡abc   Jasmin A. Holz,‡b   Yadan Ding,bcd   Xiaomin Liu,a   Youlin Zhang,a   Langping Tu,a   Xianggui Kong,*a   Bram Priem,b   Annemarie Nadort,b   Saskia A. G. Lambrechts,b   Maurice C. G. Aalders,*b   Wybren Jan Buma,c   Yichun Liud  and  Hong Zhang*c  

* Corresponding authors

a State Key Laboratory of Luminescence and Application, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033, P. R. China
E-mail: xgkong14@ciomp.ac.cn

b Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, P.O. Box 22700, The Netherlands
E-mail: m.c.aalders@amc.uva.nl

c Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
E-mail: h.zhang@uva.nl

d Centre for Advanced Optoelectronic Functional Materials Research, Key Laboratory for UV Light-Emitting Materials and Technology of the Ministry of Education, Northeast Normal University, Changchun 130024, P. R. China

Abstract

In vivo detection of cancer at an early-stage, i.e. smaller than 2 mm, is a challenge in biomedicine. In this work target labeling of an early-stage tumor spheroid (∼500 μm) is realized for the first time in a chick embryo chorioallantoic membrane (CAM) model with monoclonal antibody functionalized upconversion nanoparticles (UCNPs-mAb).

Graphical abstract: Targeted labeling of an early-stage tumor spheroid in a chorioallantoic membrane model with upconversion nanoparticles

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Article information

DOI
https://doi.org/10.1039/C4NR05638H
Article type
Communication
Submitted
26 Sep 2014
Accepted
26 Oct 2014
First published
03 Nov 2014

Nanoscale, 2015,7, 1596-1600

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Targeted labeling of an early-stage tumor spheroid in a chorioallantoic membrane model with upconversion nanoparticles

K. Liu, J. A. Holz, Y. Ding, X. Liu, Y. Zhang, L. Tu, X. Kong, B. Priem, A. Nadort, S. A. G. Lambrechts, M. C. G. Aalders, W. J. Buma, Y. Liu and H. Zhang, Nanoscale, 2015, 7, 1596 DOI: 10.1039/C4NR05638H

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