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Issue 5, 2015
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Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors

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Abstract

Therapeutic drug delivery across the blood-brain barrier (BBB) is not only inefficient, but also nonspecific to brain stroma. These are major limitations in the effective treatment of brain cancer. Transferrin peptide (Tfpep) targeted gold nanoparticles (Tfpep-Au NPs) loaded with the photodynamic pro-drug, Pc 4, have been designed and compared with untargeted Au NPs for delivery of the photosensitizer to brain cancer cell lines. In vitro studies of human glioma cancer lines (LN229 and U87) overexpressing the transferrin receptor (TfR) show a significant increase in cellular uptake for targeted conjugates as compared to untargeted particles. Pc 4 delivered from Tfpep-Au NPs clusters within vesicles after targeting with the Tfpep. Pc 4 continues to accumulate over a 4 hour period. Our work suggests that TfR-targeted Au NPs may have important therapeutic implications for delivering brain tumor therapies and/or providing a platform for noninvasive imaging.

Graphical abstract: Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors

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Publication details

The article was received on 22 Aug 2014, accepted on 21 Nov 2014 and first published on 28 Nov 2014


Article type: Paper
DOI: 10.1039/C4NR04853A
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Citation: Nanoscale, 2015,7, 1782-1790
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    Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors

    S. Dixit, T. Novak, K. Miller, Y. Zhu, M. E. Kenney and A. Broome, Nanoscale, 2015, 7, 1782
    DOI: 10.1039/C4NR04853A

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