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Issue 4, 2015
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Marine natural products that interfere with multiple cytoskeletal protein interactions

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Abstract

Covering: up to 2014

Various marine natural products that target cytoskeletal proteins have been discovered. A few of these compounds have recently been shown to induce or inhibit protein–protein interactions. Lobophorolide, an actin filament-disrupting macrolide, binds to actin with a unique 2 : 2 stoichiometry in which two lobophorolide molecules cooperate to stabilize an actin dimer. Adociasulfates, merotriterpenoid derivatives, inhibit microtubule-stimulated ATPase activity of a motor protein kinesin by blocking both the binding of microtubules and the processive motion of kinesin along microtubules. The antitumor macrolide aplyronine A synergistically binds to tubulin in association with actin, and prevents spindle formation and mitosis. In this highlight, we address recent chemical biology studies on these mechanistically-attractive marine natural products. These findings may be useful for the design and development of new pharmacological tools and therapeutic agents.

Graphical abstract: Marine natural products that interfere with multiple cytoskeletal protein interactions

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Article information


Submitted
02 Oct 2014
First published
16 Dec 2014

Nat. Prod. Rep., 2015,32, 534-542
Article type
Highlight
Author version available

Marine natural products that interfere with multiple cytoskeletal protein interactions

M. Kita and H. Kigoshi, Nat. Prod. Rep., 2015, 32, 534
DOI: 10.1039/C4NP00129J

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