Issue 9, 2015

A simple and efficient one-pot synthesis of 2-alkyl/aryl/pyridyl substituted 2H-chromenes

Abstract

A simple and efficient protocol is demonstrated to synthesize medicinally significant new 2-pyridyl/aryl/alkyl substituted 2H-chromenes. The construction of these chromene systems was through a chemoselective Knoevenagel condensation/hemiketalisation process. The reaction afforded a variety of products in good to excellent yields. This methodology has potential applications in the synthesis of biologically and medicinally relevant molecules. For the first time we have synthesized 2-pyridyl/aryl substituted 2H-chromenes in a one-pot reaction.

Graphical abstract: A simple and efficient one-pot synthesis of 2-alkyl/aryl/pyridyl substituted 2H-chromenes

Supplementary files

Article information

Article type
Paper
Submitted
01 Jun 2015
Accepted
06 Jul 2015
First published
07 Jul 2015

New J. Chem., 2015,39, 7164-7171

A simple and efficient one-pot synthesis of 2-alkyl/aryl/pyridyl substituted 2H-chromenes

L. Chandrasekhara Rao, N. Satish Kumar, N. Jagadeesh Babu and H. Mitaram Meshram, New J. Chem., 2015, 39, 7164 DOI: 10.1039/C5NJ01377A

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