Fluorescence imaging of a new monofunctional platinum(II) complex containing a thioflavin-T (ThT)-based fluorophore

Zhanfen Chen; Shuping Zhang; Lei Shen; Zhenzhu Zhu; Jian Zhang

doi:10.1039/C5NJ00107B

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Fluorescence imaging of a new monofunctional platinum(ii) complex containing a thioflavin-T (ThT)-based fluorophore†

Zhanfen Chen,*^a Shuping Zhang,^a Lei Shen,^a Zhenzhu Zhu^b and Jian Zhang^a

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* Corresponding authors

^a Hubei Collaborative Innovation Center for Rare Metal Chemistry, Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemisry & Chemical Engineering, Hubei Normal University, Huangshi 435002, China
E-mail: chenzf1979@163.com
Fax: +86 714 6515602

^b State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

Abstract

A new fluorescent monofunctional Pt(II) complex, [PtLCl]Cl (L = 4′-bis(pyridine-2-ylmethyl)amino-2-phenylbenzothiazole), has been synthesized and characterized. The complex is suitable for fluorescence imaging in living cells, which is valuable for studying the cellular processing of anticancer monofunctional platinum(II) compounds and for bringing new insights into their cellular mechanism.

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Article information

DOI: https://doi.org/10.1039/C5NJ00107B
Article type: Letter
Submitted: 14 Jan 2015
Accepted: 20 Jan 2015
First published: 20 Jan 2015

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New J. Chem., 2015,39, 1592-1596

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Fluorescence imaging of a new monofunctional platinum(II) complex containing a thioflavin-T (ThT)-based fluorophore

Z. Chen, S. Zhang, L. Shen, Z. Zhu and J. Zhang, New J. Chem., 2015, 39, 1592 DOI: 10.1039/C5NJ00107B

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New Journal of Chemistry

Fluorescence imaging of a new monofunctional platinum(ii) complex containing a thioflavin-T (ThT)-based fluorophore†

Abstract

Supplementary files

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Fluorescence imaging of a new monofunctional platinum(II) complex containing a thioflavin-T (ThT)-based fluorophore

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