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Issue 6, 2015
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Piperazine derivatives of boronic acids – potential bifunctional biologically active compounds

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Abstract

The combination of a piperazine and boronic groups within one molecule can result in a totally novel biological activity. A series of benzyl piperazine derivatives of boronic acids have been obtained by the facile and effective method based on the amination-reduction reaction of 2-formylphenylboronic acid with N-substituted piperazines. The molecular and crystal structures of six novel derivatives have been investigated, along with Hirshfeld surface analysis and hydrogen bond energy estimation. The studied compounds display several structural features that make them promising candidates as biologically active compounds.

Graphical abstract: Piperazine derivatives of boronic acids – potential bifunctional biologically active compounds

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Supplementary files

Article information


Submitted
12 Jan 2015
Accepted
16 Mar 2015
First published
17 Mar 2015

New J. Chem., 2015,39, 4308-4315
Article type
Paper
Author version available

Piperazine derivatives of boronic acids – potential bifunctional biologically active compounds

A. Adamczyk-Woźniak, K. Czerwińska, I. D. Madura, A. Matuszewska, A. Sporzyński and A. Żubrowska-Zembrzuska, New J. Chem., 2015, 39, 4308
DOI: 10.1039/C5NJ00084J

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