Synthesis of novel types of polyester glycodendrimers as potential inhibitors of urinary tract infections

Abstract

Syntheses of highly mannosylated polyester dendrimers with 2, 4, 8, and 16 α-D-mannopyranose residues on their peripheries connected by different linker arms are presented. Attractive features of these systems as potential inhibitors of uropathogenic Escherichia coli (UPEC) include the use of non-toxic and biocompatible polyester dendrimer backbones, aglycones whose lengths are designed to fit in the tyrosine gate, and multiple copies of α-linked D-mannopyranose residues, capable of effectively binding to the exposed mannose-sensitive type 1 pili on UPEC's outer surface.