Jump to main content
Jump to site search

Issue 9, 2015
Previous Article Next Article

Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis

Author affiliations

Abstract

The functional link between zinc homeostasis and membrane-related processes, including lipid metabolism regulation, extends from yeast to humans, and has a likely role in the pathogenesis of diabetes. The yeast Izh2 protein has been previously implicated in zinc ion homeostasis and in the regulation of lipid and phosphate metabolism, but its precise molecular function is not known. We performed a chemogenomics experiment to determine the genes conferring resistance or sensitivity to different environmental zinc concentrations. We then determined at normal, depleted and excess zinc concentrations, the genetic interactions of IZH2 at the genome-wide level and measured changes in the transcriptome caused by deletion of IZH2. We found evidence for an important cellular function of the Rim101 pathway in zinc homeostasis in neutral or acidic environments, and observed that phosphatidylinositol is a source of inositol when zinc availability is limited. Comparison of our experimental profiles with published gene expression and genetic interaction profiles revealed pleiotropic functions for Izh2. We propose that Izh2 acts as an integrator of intra- and extracellular signals in providing adequate cellular responses to maintain homeostasis under different external conditions, including – but not limited to – alterations in zinc concentrations.

Graphical abstract: Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Apr 2015, accepted on 29 May 2015 and first published on 29 May 2015


Article type: Paper
DOI: 10.1039/C5MT00095E
Author version
available:
Download author version (PDF)
Citation: Metallomics, 2015,7, 1338-1351
  •   Request permissions

    Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis

    M. Mattiazzi Ušaj, M. Prelec, M. Brložnik, C. Primo, T. Curk, J. Ščančar, L. Yenush and U. Petrovič, Metallomics, 2015, 7, 1338
    DOI: 10.1039/C5MT00095E

Search articles by author

Spotlight

Advertisements