Issue 7, 2015
From the journal:

MedChemComm

Synthesis of unusual isoxazoline containing β and γ-dipeptides as potential glutamate receptor ligands†

Lucia Tamborini,*a   Federica Mastronardi,a   Federica Dall'Oglio,a   Carlo De Micheli,a   Birgitte Nielsen,b   Leonardo Lo Presti,c   Paola Contia  and  Andrea Pintoa  

* Corresponding authors

a Dipartimento di Scienze Farmaceutiche DISFARM, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy
E-mail: lucia.tamborini@unimi.it
Fax: +39 0250319326
Tel: +39 0250319322

b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen OE, Denmark

c Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy

Abstract

New unconventional beta and gamma dipeptides, representing conformationally constrained higher homologues of glutamic acid, have been prepared and tested as new pharmacological tools to investigate the iGluR binding domain, in an attempt to identify potential selective antagonists.

Graphical abstract: Synthesis of unusual isoxazoline containing β and γ-dipeptides as potential glutamate receptor ligands

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Article information

DOI
https://doi.org/10.1039/C5MD00159E
Article type
Concise Article
Submitted
17 Apr 2015
Accepted
14 May 2015
First published
15 May 2015

Med. Chem. Commun., 2015,6, 1260-1266

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Synthesis of unusual isoxazoline containing β and γ-dipeptides as potential glutamate receptor ligands

L. Tamborini, F. Mastronardi, F. Dall'Oglio, C. De Micheli, B. Nielsen, L. Lo Presti, P. Conti and A. Pinto, Med. Chem. Commun., 2015, 6, 1260 DOI: 10.1039/C5MD00159E

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