Jump to main content
Jump to site search

Issue 7, 2015
Previous Article Next Article

Identification of an indole–triazole–amino acid conjugate as a highly effective antifungal agent

Author affiliations

Abstract

Compounds constructed by the grafting of amino acid and triazole with an indole moiety were synthesized and investigated for antifungal activities wherein one of the compounds gave highly promising results. Although the compound has a high MIC80 value in liquid medium, it shows significant antifungal activity against Candida albicans in solid plate assays. The compound is found to target chitin in the cell wall and lanosterol 14α-demethylase of the ergosterol biosynthesis pathway. The inhibitory effect of the compound becomes more pronounced in combination with azoles and CFW. The compound is also found to significantly affect chitin levels, cell morphology and cell viability in combination with ketoconazole.

Graphical abstract: Identification of an indole–triazole–amino acid conjugate as a highly effective antifungal agent

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Apr 2015, accepted on 25 May 2015 and first published on 26 May 2015


Article type: Concise Article
DOI: 10.1039/C5MD00156K
Med. Chem. Commun., 2015,6, 1352-1359

  •   Request permissions

    Identification of an indole–triazole–amino acid conjugate as a highly effective antifungal agent

    K. Pawar, A. Yadav, P. Prasher, S. Mishra, B. Singh, P. Singh and S. S. Komath, Med. Chem. Commun., 2015, 6, 1352
    DOI: 10.1039/C5MD00156K

Search articles by author

Spotlight

Advertisements