Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells†
Abstract
On the basis of previous research showing the capability of N-carbobenzyloxy-(Z-)amino acid-
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* Corresponding authors
a
Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy
E-mail:
antonello.mai@uniroma1.it
b Department of Biology and Biotechnology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
c Genextra Group, DAC s.r.l. Via Adamello 16, 20139 Milano, Italy
d Department of Experimental Oncology, European Institute of Oncology IEO, Via Adamello 16, 20139 Milan, Italy
e Department of Biosciences, University of Milan, 20100 Milan, Italy
f Pasteur Institute - Cenci Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy
On the basis of previous research showing the capability of N-carbobenzyloxy-(Z-)amino acid-
V. Rodriguez, S. Valente, S. Rovida, D. Rotili, G. Stazi, A. Lucidi, G. Ciossani, A. Mattevi, O. A. Botrugno, P. Dessanti, C. Mercurio, P. Vianello, S. Minucci, M. Varasi and A. Mai, Med. Chem. Commun., 2015, 6, 665 DOI: 10.1039/C4MD00507D
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