Synthetic spirocyclic endoperoxides: new antimalarial scaffolds†
Abstract
Here we report the development of a straightforward synthetic procedure for the preparation of spirocyclic endoperoxides as synthetic analogues of the
* Corresponding authors
a
European Research Centre for Drug Discovery and Development (NatSynDrug), University of Siena, via Aldo Moro 2, Siena, Italy
E-mail:
gemma@unisi.it, campiani@unisi.it
b Dip. di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, Siena, Italy
c Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy
d Dip. di Scienze Farmacologiche e Biomolecolari, Università di Milano, Via Pascal 36, 20133 Milan, Italy
e School of Pharmacy, University of Camerino, Piazza Cavour 19F, 62032 Camerino, Italy
f Dip. di Farmacia, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy
Here we report the development of a straightforward synthetic procedure for the preparation of spirocyclic endoperoxides as synthetic analogues of the
M. Brindisi, S. Gemma, S. Kunjir, L. Di Cerbo, S. Brogi, S. Parapini, S. D'Alessandro, D. Taramelli, A. Habluetzel, S. Tapanelli, S. Lamponi, E. Novellino, G. Campiani and S. Butini, Med. Chem. Commun., 2015, 6, 357 DOI: 10.1039/C4MD00454J
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