Issue 1, 2015
From the journal:

MedChemComm

Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines†

Guilherme A. M. Jardim,a   Tiago T. Guimarães,b   Maria do Carmo F. R. Pinto,c   Bruno C. Cavalcanti,d   Kaio M. de Farias,d   Claudia Pessoa,de   Claudia C. Gatto,f   Divya K. Nair,g   Irishi N. N. Namboothiri*g  and  Eufrânio N. da Silva Júnior*a  

* Corresponding authors

a Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte-MG, Brazil
E-mail: eufranio@ufmg.br
Fax: +55 31 34095700
Tel: +55 31 34095720

b Instituto Nacional de Câncer, Hospital do Câncer – Unidade I – Seção de Medicina Nuclear, Rio de Janeiro, RJ, Brazil

c Núcleo de Pesquisas de Produtos Naturais, UFRJ, Rio de Janeiro, RJ, Brazil

d Departamento de Fisiologia e Farmacologia, UFC, Fortaleza, CE, Brazil

e Fiocruz – Ceará, Fortaleza, CE, Brazil

f Institute of Chemistry, University of Brasilia, Brasilia-DF, Brazil

g Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400 076, India
E-mail: irishi@iitb.ac.in
Fax: +91-22-2576-7152
Tel: +91-22-2576-7196

Abstract

Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-nor-β-lapachone and amino-chalcones. Lapachone derivatives are also described here. All the substances were evaluated against cancer and normal cell lines and several compounds demonstrated potent antitumor activity.

Graphical abstract: Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

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Article information

DOI
https://doi.org/10.1039/C4MD00371C
Article type
Concise Article
Submitted
28 Aug 2014
Accepted
19 Sep 2014
First published
24 Sep 2014

Med. Chem. Commun., 2015,6, 120-130

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Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines

G. A. M. Jardim, T. T. Guimarães, M. D. C. F. R. Pinto, B. C. Cavalcanti, K. M. de Farias, C. Pessoa, C. C. Gatto, D. K. Nair, I. N. N. Namboothiri and E. N. da Silva Júnior, Med. Chem. Commun., 2015, 6, 120 DOI: 10.1039/C4MD00371C

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