Thermoresponsive release of viable microfiltrated Circulating Tumor Cells (CTCs) for precision medicine applications

Zheng Ao; Erika Parasido; Siddarth Rawal; Anthony Williams; Richard Schlegel; Stephen Liu; Chris Albanese; Richard J. Cote; Ashutosh Agarwal; Ram H. Datar

doi:10.1039/C5LC01024A

Thermoresponsive release of viable microfiltrated Circulating Tumor Cells (CTCs) for precision medicine applications†

Zheng Ao,^a Erika Parasido,^b Siddarth Rawal,^a Anthony Williams,^a Richard Schlegel,^b Stephen Liu,^b Chris Albanese,^b Richard J. Cote,^a Ashutosh Agarwal*^ac and Ram H. Datar^a

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* Corresponding authors

^a Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
E-mail: A.agarwal2@miami.edu
Fax: +1 305 243 6170
Tel: +1 305 243 8925

^b Departments of Oncology and Pathology, and the Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, USA

^c Department of Biomedical Engineering, University of Miami, USA

Abstract

Stimulus responsive release of Circulating Tumor Cells (CTCs), with high recovery rates from their capture platform, is highly desirable for off-chip analyses. Here, we present a temperature responsive polymer coating method to achieve both release as well as culture of viable CTCs captured from patient blood samples.

Lab on a Chip

Thermoresponsive release of viable microfiltrated Circulating Tumor Cells (CTCs) for precision medicine applications†

Abstract

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Thermoresponsive release of viable microfiltrated Circulating Tumor Cells (CTCs) for precision medicine applications

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