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Issue 24, 2015
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Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc

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Abstract

We investigate the deformation characteristics of red blood cells (RBCs) on a rotating compact disc platform. Our study brings out the interplay between haemoglobin content and RBC deformability in a centrifugally actuated microfluidic environment. We reveal that RBC deformations follow the similar trend of principal stress distributed throughout the radial direction, rendering an insight into the mechano-physical processes involved. This study can be used as a diagnostic marker to determine haematological disorders in diseased blood samples tested on compact disc based microfluidic platforms.

Graphical abstract: Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc

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Article information


Submitted
12 Aug 2015
Accepted
12 Oct 2015
First published
12 Oct 2015

Lab Chip, 2015,15, 4571-4577
Article type
Paper
Author version available

Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc

S. Kar, U. Ghosh, T. K. Maiti and S. Chakraborty, Lab Chip, 2015, 15, 4571
DOI: 10.1039/C5LC00968E

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