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Issue 17, 2015
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A cyclically actuated electrolytic drug delivery device

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Abstract

This work, focusing on an implantable drug delivery system, presents the first prototype electrolytic pump that combines a catalytic reformer and a cyclically actuated mode. These features improve the release performance and extend the lifetime of the device. Using our platinum (Pt)-coated carbon fiber mesh that acts as a catalytic reforming element, the cyclical mode is improved because the faster recombination rate allows for a shorter cycling time for drug delivery. Another feature of our device is that it uses a solid-drug-in-reservoir (SDR) approach, which allows small amounts of a solid drug to be dissolved in human fluid, forming a reproducible drug solution for long-term therapies. We have conducted proof-of-principle drug delivery studies using such an electrolytic pump and solvent blue 38 as the drug substitute. These tests demonstrate power-controlled and pulsatile release profiles of the chemical substance, as well as the feasibility of this device. A drug delivery rate of 11.44 ± 0.56 μg min−1 was achieved by using an input power of 4 mW for multiple pulses, which indicates the stability of our system.

Graphical abstract: A cyclically actuated electrolytic drug delivery device

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Article information


Submitted
22 Jun 2015
Accepted
09 Jul 2015
First published
09 Jul 2015

Lab Chip, 2015,15, 3540-3548
Article type
Paper
Author version available

A cyclically actuated electrolytic drug delivery device

Y. Yi, U. Buttner and I. G. Foulds, Lab Chip, 2015, 15, 3540
DOI: 10.1039/C5LC00703H

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