Issue 6, 2015

Fast ion chromatography-ICP-QQQ for arsenic speciation

Abstract

Two methods for the fast separation of arsenic species are presented. The general approach is to modify existing methodology utilizing carbonate eluents for a small particle size, short column length Hamilton PRP-X100 column which is interfaced with the Agilent 8800 ICP-QQQ using oxygen as reaction gas and detection of AsO at m/z 91. Using H2O2 in the extractant to oxidize As(III) to As(V) it is possible to separate arsenobetaine from DMA, MMA and As(V) in 1.5 minutes. Such a method may be useful where a measure of total inorganic As is sufficient, for example for regulatory compliance in food or beverage testing. It is possible to separate six As species. i.e. the four above and arsenocholine and As(III) in 4.5 minutes using a gradient separation. Such a method could be useful for analysis of urinary arsenic species. Coupling with the high sensitivity of ICP-QQQ yields equivalent or better detection limits than conventional methods with run times up to 5 times faster, which is a significant benefit for sample throughput and method development.

Graphical abstract: Fast ion chromatography-ICP-QQQ for arsenic speciation

Article information

Article type
Technical Note
Submitted
13 Feb 2015
Accepted
27 Mar 2015
First published
27 Mar 2015

J. Anal. At. Spectrom., 2015,30, 1405-1407

Author version available

Fast ion chromatography-ICP-QQQ for arsenic speciation

B. P. Jackson, J. Anal. At. Spectrom., 2015, 30, 1405 DOI: 10.1039/C5JA00049A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements