Jump to main content
Jump to site search

Issue 10, 2015
Previous Article Next Article

Modeling the finger instability in an expanding cell monolayer

Author affiliations


Collective motion occurs in many biological processes, such as wound healing, tumor invasion and embryogenesis. Experiments of cell monolayer migration have revealed the spontaneous formation of finger-like instabilities, with leader cells at their tips. We present a particle-based model for collective cell migration, based on several elements that have been found experimentally to influence cellular movement. Inside the bulk we include velocity alignment interactions between neighboring cells. At the border contour of the layer we introduce the following additional forces: surface-elasticity restoring force, curvature-dependent positive feedback, and contractile acto-myosin cables. We find that the curvature-driven instability at the layer edge is necessary and sufficient for the formation of cellular fingers, which are in good agreement with experimental observations.

Graphical abstract: Modeling the finger instability in an expanding cell monolayer

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Apr 2015, accepted on 07 Jun 2015 and first published on 10 Jun 2015

Article type: Paper
DOI: 10.1039/C5IB00092K
Author version
Download author version (PDF)
Citation: Integr. Biol., 2015,7, 1218-1227

Search articles by author