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Issue 2, 2015
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Regioselective synthesis of functionalized [1,8]naphthyridine derivatives via three-component domino reaction under catalyst-free conditions

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Abstract

A concise and efficient one-pot synthesis of functionalized [1,8]naphthyridine derivatives via a three-component domino reaction of glutaraldehyde, malononitrile, and β-ketoamides, under catalyst-free conditions in an environmentally friendly medium (ethanol) is described. The main advantages of this protocol are short reaction times, practical simplicity, high yields, catalyst-free conditions, cheap and benign solvents, and high regio- and stereo-selectivities.

Graphical abstract: Regioselective synthesis of functionalized [1,8]naphthyridine derivatives via three-component domino reaction under catalyst-free conditions

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Publication details

The article was received on 31 Jul 2014, accepted on 28 Sep 2014 and first published on 30 Sep 2014


Article type: Paper
DOI: 10.1039/C4GC01469C
Green Chem., 2015,17, 973-981

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    Regioselective synthesis of functionalized [1,8]naphthyridine derivatives via three-component domino reaction under catalyst-free conditions

    X. Feng, J. Wang, J. Zhang, C. Cao, Z. Huang and D. Shi, Green Chem., 2015, 17, 973
    DOI: 10.1039/C4GC01469C

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