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Issue 9, 2015
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Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst- and solvent-free thermal multicomponent domino reaction

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Abstract

An efficient and highly eco-friendly synthesis of diverse and functionalized 2-pyridone derivatives in good yield via the thermal multicomponent reaction of 4-oxo-4H-chromene-3-carbaldehydes with 1,3-diketoesters and anilines or primary aliphatic amines under catalyst- and solvent-free conditions is described. This reaction proceeds via domino Knoevenagel condensation/Michael addition/ring opening/ring closure reactions.

Graphical abstract: Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst- and solvent-free thermal multicomponent domino reaction

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Publication details

The article was received on 07 Jul 2015, accepted on 15 Jul 2015 and first published on 29 Jul 2015


Article type: Paper
DOI: 10.1039/C5GC01526J
Green Chem., 2015,17, 4579-4586

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    Eco-friendly synthesis of diverse and valuable 2-pyridones by catalyst- and solvent-free thermal multicomponent domino reaction

    T. N. Poudel, Y. R. Lee and S. H. Kim, Green Chem., 2015, 17, 4579
    DOI: 10.1039/C5GC01526J

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