Issue 4, 2015
From the journal:

Green Chemistry

Fast, solvent-free, highly enantioselective three-component coupling of aldehydes, alkynes, and amines catalysed by the copper(ii)pybox complex under high-vibration ball-milling†

Zhenhua Li,ab   Zhijiang Jiangab  and  Weike Su*ab  

* Corresponding authors

a Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China
E-mail: pharmlab@zjut.edu.cn

b College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China

Abstract

Chiral propargylamines were synthesized in good to excellent yields with high enantioselectivity via Cu(OTf)2/Ph-Pybox catalysed, solvent-free three-component asymmetric coupling of aldehydes, alkynes and amines by ball-milling within 60 minutes. The catalytic system can be reused several times without losing the activity.

Graphical abstract: Fast, solvent-free, highly enantioselective three-component coupling of aldehydes, alkynes, and amines catalysed by the copper(ii)pybox complex under high-vibration ball-milling

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Article information

DOI
https://doi.org/10.1039/C5GC00079C
Article type
Communication
Submitted
15 Jan 2015
Accepted
09 Feb 2015
First published
09 Feb 2015

Green Chem., 2015,17, 2330-2334

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Fast, solvent-free, highly enantioselective three-component coupling of aldehydes, alkynes, and amines catalysed by the copper(II)pybox complex under high-vibration ball-milling

Z. Li, Z. Jiang and W. Su, Green Chem., 2015, 17, 2330 DOI: 10.1039/C5GC00079C

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