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Issue 2, 2015
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Preliminary toxicity and ecotoxicity assessment of methyltrioxorhenium and its derivatives

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Abstract

Methyltrioxorhenium (MTO) is one of the best examined catalysts for the activation of H2O2 in oxidation reactions, particularly olefin epoxidation reactions. The broad applicability and high activity of MTO and MTO Lewis base adducts combined with their selectivity for a variety of processes have also generated industrial interest. In compliance with the basic principles of green chemistry, however, the optimization of the technological properties of chemicals should be investigated in parallel with the minimization of their (eco)toxicological hazard potential. The toxicity of MTO and its complexes towards human health and the environment has not been investigated so far. Performed in close cooperation between industry and academia, the present study aims to fill this knowledge gap by systematically assessing the (eco)toxicity of MTO and its derivatives at different levels of biological organisation. Instrumental analysis was used to investigate the stability and solubility of the target compounds in biological media. The initial evaluation of the hazard potential of MTO shows that it causes strong short-term (eco)toxicological effects and offers preliminary indications of its genotoxic potential. In this light it appears important to prevent the release of MTO into the environment and the exposure of operators; the necessary safety precautions should be taken. The fast decomposition of MTO in aqueous media, on the other hand, leads to perrhenates, which exhibit a much lower (eco)toxicological hazard potential.

Graphical abstract: Preliminary toxicity and ecotoxicity assessment of methyltrioxorhenium and its derivatives

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Supplementary files

Article information


Submitted
02 Oct 2014
Accepted
10 Nov 2014
First published
10 Nov 2014

This article is Open Access

Green Chem., 2015,17, 1136-1144
Article type
Paper
Author version available

Preliminary toxicity and ecotoxicity assessment of methyltrioxorhenium and its derivatives

S. Stolte, H. T. T. Bui, S. Steudte, V. Korinth, J. Arning, A. Białk-Bielińska, U. Bottin-Weber, M. Cokoja, A. Hahlbrock, V. Fetz, R. Stauber, B. Jastorff, C. Hartmann, R. W. Fischer and F. E. Kühn, Green Chem., 2015, 17, 1136
DOI: 10.1039/C4GC01919A

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