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Issue 2, 2015
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Eco-friendly synthesis of pyridines via rhodium-catalyzed cyclization of diynes with oximes

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Abstract

We describe a new route for the synthesis of pyridines via [2 + 2 + 2] cycloaddition of diynes and oximes catalyzed by Rh(NBD)2BF4/MeO-Biphep using ethanol as an alternative green reaction medium, affording the desired pyridine derivatives in yields of up to 93%. This environmentally friendly method meets the requirement for green chemistry by minimizing pollution from solvents and is tolerant of a range of functional groups.

Graphical abstract: Eco-friendly synthesis of pyridines via rhodium-catalyzed cyclization of diynes with oximes

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Article information


Submitted
10 Sep 2014
Accepted
28 Oct 2014
First published
03 Nov 2014

Green Chem., 2015,17, 799-803
Article type
Communication
Author version available

Eco-friendly synthesis of pyridines via rhodium-catalyzed cyclization of diynes with oximes

F. Xu, C. Wang, H. Wang, X. Li and B. Wan, Green Chem., 2015, 17, 799
DOI: 10.1039/C4GC01756K

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