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Issue 8, 2015
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d-Fagomine attenuates metabolic alterations induced by a high-energy-dense diet in rats

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Abstract

D-Fagomine is a natural iminosugar that counteracts the short-term effects of a high-energy-dense diet on body weight, fasting blood glucose levels and the proportion of gut Enterobacteriales. This suggests that supplementation with D-fagomine for longer periods may delay the onset of other factors related to metabolic syndrome. Here we evaluate the effects of D-fagomine dietary supplementation on relevant metabolic hormones and lipid peroxidation. Adult Sprague–Dawley rats were fed a high-fat high-sucrose diet supplemented or not with D-fagomine (0.065% w/w) for 9 weeks. Weight gain, plasma triglycerides, glucose, insulin, glucagon, ghrelin, leptin, and urine F2-isoprostanes were evaluated. D-Fagomine attenuated the changes induced by the high-energy-dense diet in triglycerides and all the hormones tested. These results suggest that D-fagomine may help to avert the complications associated with unhealthy eating by counteracting the effects of high-energy-dense diets during the early stages of the development of metabolic disorders.

Graphical abstract: d-Fagomine attenuates metabolic alterations induced by a high-energy-dense diet in rats

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Article information


Submitted
22 May 2015
Accepted
09 Jun 2015
First published
10 Jun 2015

Food Funct., 2015,6, 2614-2619
Article type
Paper

D-Fagomine attenuates metabolic alterations induced by a high-energy-dense diet in rats

E. Molinar-Toribio, J. Pérez-Jiménez, S. Ramos-Romero, L. Gómez, N. Taltavull, M. R. Nogués, A. Adeva, O. Jáuregui, J. Joglar, P. Clapés and J. L. Torres, Food Funct., 2015, 6, 2614 DOI: 10.1039/C5FO00591D

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