Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.

Issue 10, 2015
Previous Article Next Article

The structure of wheat bread influences the postprandial metabolic response in healthy men

Author affiliations


Postprandial high glucose and insulin responses after starchy food consumption, associated with an increased risk of developing several metabolic diseases, could possibly be improved by altering food structure. We investigated the influence of a compact food structure; different wheat products with a similar composition were created using different processing conditions. The postprandial glucose kinetics and metabolic response to bread with a compact structure (flat bread, FB) was compared to bread with a porous structure (control bread, CB) in a randomized, crossover study with ten healthy male volunteers. Pasta (PA), with a very compact structure, was used as the control. The rate of appearance of exogenous glucose (RaE), endogenous glucose production, and glucose clearance rate (GCR) was calculated using stable isotopes. Furthermore, postprandial plasma concentrations of glucose, insulin, several intestinal hormones and bile acids were analyzed. The structure of FB was considerably more compact compared to CB, as confirmed by microscopy, XRT analysis (porosity) and density measurements. Consumption of FB resulted in lower peak glucose, insulin and glucose-dependent insulinotropic polypeptide (ns) responses and a slower initial RaE compared to CB. These variables were similar to the PA response, except for RaE which remained slower over a longer period after PA consumption. Interestingly, the GCR after FB was higher than expected based on the insulin response, indicating increased insulin sensitivity or insulin-independent glucose disposal. These results demonstrate that the structure of wheat bread can influence the postprandial metabolic response, with a more compact structure being more beneficial for health. Bread-making technology should be further explored to create healthier products.

Graphical abstract: The structure of wheat bread influences the postprandial metabolic response in healthy men

Back to tab navigation

Supplementary files

Article information

05 Apr 2015
28 Jul 2015
First published
07 Aug 2015

Food Funct., 2015,6, 3236-3248
Article type
Author version available

The structure of wheat bread influences the postprandial metabolic response in healthy men

C. Eelderink, M. W. J. Noort, N. Sozer, M. Koehorst, J. J. Holst, C. F. Deacon, J. F. Rehfeld, K. Poutanen, R. J. Vonk, L. Oudhuis and M. G. Priebe, Food Funct., 2015, 6, 3236
DOI: 10.1039/C5FO00354G

Social activity

Search articles by author